A 1-year multicenter placebo-controlled study of acetyl-L-carnitine in patients with Alzheimer's Disease. View abstract. In one study, people who took 3 grams every day for 21 days experienced no negative effects (57). Van Oudheusden, L. J. and Scholte, H. R. Efficacy of carnitine in the treatment of children with attention-deficit hyperactivity disorder. Signorelli, S. S., Fatuzzo, P., Rapisarda, F., Neri, S., Ferrante, M., Oliveri, Conti G., Fallico, R., Di, Pino L., Pennisi, G., Celotta, G., and Massimiliano, A. Payne, C., Wiffen, P. J., and Martin, S. Interventions for fatigue and weight loss in adults with advanced progressive illness. View abstract. Pastoris, O., Dossena, M., Foppa, P., Catapano, M., Arbustini, E., Bellini, O., Dal Bello, B., Minzioni, G., Ceriana, P., and Barzaghi, N. Effect of L-carnitine on myocardial metabolism: results of a balanced, placebo-controlled, double-blind study in patients undergoing open heart surgery. Clinical Trials Journal 1986;23(6):338-344. Georges B, Galland S, Rigault C, et al. Korean J.Nutrition 2007;40(7):630-638. There are several effective supplements that can help you burn body fat. Watanabe, S., Ajisaka, R., Masuoka, T., Yamanouchi, T., Saitou, T., Toyama, M., Takeyasu, N., Sakamoto, K., and Sugishita, Y. A randomized, double-blind, placebo-controlled trial of L-carnitine in suspected acute myocardial infarction. Costa, M., Canale, D., Filicori, M., D'lddio, S., and Lenzi, A. L-carnitine in idiopathic asthenozoospermia: a multicenter study. One study of people with type 2 diabetes taking anti-diabetic medication indicated that carnitine supplements significantly reduced blood sugar levels, compared to a placebo (55). Acute and chronic effects of propionyl-L-carnitine on the hemodynamics, exercise capacity, and hormones in patients with congestive heart failure. Corbucci, G. G., Menichetti, A., Cogliatti, A., Nicoli, P., and Ruvolo, C. Metabolic aspects of acute tissue hypoxia during extracorporeal circulation and their modification induced by L-carnitine treatment. Acta Neurol.Taiwan. What is carnipure good for? [Ultimate Guide!] It can cause nausea, abdominal cramps, vomiting, and diarrhea when taken in high doses. View abstract. Common causes of insomnia include stress, an irregular sleep schedule, poor sleeping habits, mental health disorders like anxiety and depression, physical illnesses and pain, medications . Horvath, G. A., Davidson, A. G., Stockler-Ipsiroglu, S. G., Lillquist, Y. P., Waters, P. J., Olpin, S., Andresen, B. S., Palaty, J., Nelson, J., and Vallance, H. Newborn screening for MCAD deficiency: experience of the first three years in British Columbia, Canada. Lim, C. Y., Jun, D. W., Jang, S. S., Cho, W. K., Chae, J. D., and Jun, J. H. Effects of carnitine on peripheral blood mitochondrial DNA copy number and liver function in non-alcoholic fatty liver disease. New Trends Clin Neuropharmacol 1989;3(4):225-230. Zeitschrift fr Orthomolekulare Medizin 2009;7(3):22-24. View abstract. However, the human body is extremely complex, and the results of both human and animal studies are mixed (24, 25, 26, 27). View abstract. View abstract. You'll also. It also caused me to urinate a lot. Clin Nephrol. Seattle, WA: University of Washington, Seattle;1993. Vecchiet L, Di Lisa F, Pieralisi G, et al. View abstract. Cochrane.Database.Syst.Rev. Vacha, G. M., Giorcelli, G., D'Iddio, S., Valentini, G., Bagiella, E., Procopio, A., di Donato, S., Ashbrook, D., and Corsi, M. L-carnitine addition to dialysis fluid. Pivalate-generating prodrugs and carnitine homeostasis in man. [The anti-arrhythmic effect of L-carnitine in subjects with ischemic cardiopathy]. Wu X, Huang W, Prasad PD, et al. Sood, A., Barton, D. L., Bauer, B. 2010;20(11):693-700. Fenkci, S. M., Fenkci, V., Oztekin, O., Rota, S., and Karagenc, N. Serum total L-carnitine levels in non-obese women with polycystic ovary syndrome. Support Care Cancer. Circ.J 2008;72(6):926-931. carnitine and glucose/thiamine. Can Energy Drinks Cause Anxiety Attacks? - MediChannel J Nutr.Biochem. Carroll, J. K., Kohli, S., Mustian, K. M., Roscoe, J. Mercadal, L., Coudert, M., Vassault, A., Pieroni, L., Debure, A., Ouziala, M., Depreneuf, H., Fumeron, C., Servais, A., Bassilios, N., Becart, J., Assogba, U., Allouache, M., Bouali, B., Luong, N., Dousseaux, M. P., Tezenas-du, Montcel S., and Deray, G. L-carnitine treatment in incident hemodialysis patients: the multicenter, randomized, double-blinded, placebo-controlled CARNIDIAL trial. Am J Clin Nutr 1980;33(7):1489-1492. Pickard, R. Editorial comment on: Antioxidant treatment associated with sildenafil reduces monocyte activation and markers of endothelial damage in patients with diabetic erectile dysfunction: a double-blind, placebo-controlled study. View abstract. View abstract. In one study, 2 grams of L-carnitine reduced fatigue and increased muscle function in older adults. Campos Y, Arenas J. 2006;26(4):499-500. 2010;5(8):e12140. Clin Ter. Lenzi, A., Lombardo, F., Sgro, P., Salacone, P., Caponecchia, L., Dondero, F., and Gandini, L. Use of carnitine therapy in selected cases of male factor infertility: a double-blind crossover trial. Aliment.Pharmacol Ther 2011;34(9):1088-1097. Ramos AC, Barrucand L, Elias PR, et al. Colon-Soto, M., Peredo, R. A., and Vila, L. M. Systemic lupus erythematosus after mesotherapy with acetyl-L-carnitine. 2008;42(11):1686-1691. View abstract. Hooshmand, S., Balakrishnan, A., Clark, R. M., Owen, K. Q., Koo, S. I., and Arjmandi, B. H. Dietary l-carnitine supplementation improves bone mineral density by suppressing bone turnover in aged ovariectomized rats. Sum CF, Winocour PH, Agius L, and et al. Acetyl-L-carnitine (ALC) is a form of amino-acid carnitine, used as a dietary supplement and nootropic. Prog Retin Eye Res. Malaguarnera, M., Pistone, G., Astuto, M., Dell'Arte, S., Finocchiaro, G., Lo, Giudice E., and Pennisi, G. L-Carnitine in the treatment of mild or moderate hepatic encephalopathy. Heart complications (such as irregular heartbeat and heart failure). 2020;27(3):e229-e234. Quality of life during and between hemodialysis treatments: role of L- carnitine supplementation. Miyagawa T, Kawamura H, Obuchi M, Ikesaki A, Ozaki A, Tokunaga K, Inoue Y, Honda M. Effects of oral L-carnitine administration in narcolepsy patients: a randomized, double-blind, cross-over and placebo-controlled trial. For this reason, L-carnitine levels are often lower in vegetarians and vegans, since they restrict or avoid animal products (6, 62). View abstract. Take the missed dose as soon as you remember. Medically reviewed by Drugs.com. Potential role of levocarnitine supplementation for treatment of chemotherapy-induced fatigue in non-anemic cancer patients. Low Blood Pressure. Derosa, G., Maffioli, P., Salvadeo, S. A., Ferrari, I., Gravina, A., Mereu, R., D'Angelo, A., Palumbo, I., Randazzo, S., and Cicero, A. F. Sibutramine and L-carnitine compared to sibutramine alone on insulin resistance in diabetic patients. Cell Biol.Int. Gomez-Amores, L., Mate, A., Miguel-Carrasco, J. L., Jimenez, L., Jos, A., Camean, A. M., Revilla, E., Santa-Maria, C., and Vazquez, C. M. L-carnitine attenuates oxidative stress in hypertensive rats. 2016;17(10):970-6. Evans, J. D., Jacobs, T. F., and Evans, E. W. Role of acetyl-L-carnitine in the treatment of diabetic peripheral neuropathy. Clin Rheumatol. Ann.Pharmacother. View abstract. Int J Clin Pharmacol Ther Toxicol 1985;23:569-72. Gecele M, Francesetti G, and Meluzzi A. Acetyl-L-carnitine in aged subjects with major depression: clinical efficacy and effects on the circadian rhythm of cortisol. View abstract. Levocarnitine. Mol.Genet.Metab 2010;100(1):46-50. Dutta, A., Ray, K., Singh, V. K., Vats, P., Singh, S. N., and Singh, S. B. L-carnitine supplementation attenuates intermittent hypoxia-induced oxidative stress and delays muscle fatigue in rats. Of the different forms, acetyl-L-carnitine and L-carnitine are the most popular and seem to be most effective. J Mol.Histol. J Clin Endocrinol Metab 2001;86:3579-94. Follow all directions on your medicine label and package. Lai CL, Ahn SH, Lee KS, Um SH, Cho M, Yoon SK, Lee JW, Park NH, Kweon YO, Sohn JH, Lee J, Kim JA, Han KH, Yuen MF. Ann Neurol 1994;35:482-7. 2007;52(6):1775-1776. Malaguarnera M, Cammalleri L, Gargante MP, et al. Nutrients 2021;13(10):3432. Another human study monitored L-carnitines effect on fat burning during a 90-minute stationary bicycle workout. Dev Med Child Neurol 1991;33:795-802. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using. LevOCARNitine (levOCARNitine)." Potential involvement of altered carnitine palmitoyltransferase-I activity. View abstract. View abstract. View abstract. Pediatr.Neonatol. I. Carnitine concentrations and lipid effects." View abstract. Bartels GL, Remme WJ, Holwerda KJ, Kruijssen DA. 2006;49(6):987-997. Ren Fail. Am J Nephrol 1990;10(2):109-114. Clin J Am Soc Nephrol. Nagai, N., Kameda, N., Kobashi, R., Nishida, M., Horikawa, C., Egawa, K., Yoshimura, M., Kitagawa, Y., Abe, K., Kiso, Y., Sakane, N., Kotani, K., and Moritani, T. Effect of L-carnitine intake upon reduction of hunger feeling in young healthy females. Sima AAF, Calvani M, Mehra M, et al. Trivelli G, Vitali P Girmenia S Castelli F. Trattamento della dislipidemia dell'emodializzato con L-carnitina. B., Das, A. M., DeKlerk, J. Madsen KL, Preisler N, Orngreen MC, Andersen SP, Olesen JH, Lund AM, Vissing J. View abstract. Interestingly, food sources of L-carnitine have a greater absorption rate than supplements. Management and outcome in 75 individuals with long-chain fatty acid oxidation defects: results from a workshop. "Product Information. 2008;27(3):253-259. Malaguarnera, M., Vacante, M., Motta, M., Giordano, M., Malaguarnera, G., Bella, R., Nunnari, G., Rampello, L., and Pennisi, G. Acetyl-L-carnitine improves cognitive functions in severe hepatic encephalopathy: a randomized and controlled clinical trial. 2007;18(3):169-176. Rejuvenation.Res. 2010;106(4):296-301. Eidi, M., Pouyan, O., Shahmohammadi, P., Saeidi, H., Bahar, M., and Eidi, A. It is usually taken in doses from 1000 to 2000 milligrams per day . View abstract. Nephron Clin.Pract. 2011;13(5):392-395. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. List of All Orphan Products Designations and Approvals. J Strength.Cond.Res. View abstract. Clin Physiol 1995;15(5):417-423. 2008;47(10):823-825. View abstract. Antioxidant treatment with carnitines is effective in infertile patients with prostatovesiculoepididymitis and elevated seminal leukocyte concentrations after treatment with nonsteroidal anti-inflammatory compounds. Zhang, X. L. and Ge, H. Clinical observations on treating ischemic cardiomyopathy using Fasudil and L-carnitine. 2013 Sep;67(7):659-63. Iliceto S, Scrutinio D, Bruzzi P, et al. This includes older adults and people who rarely or never eat meat and fish. View abstract. View abstract. Int.J Vitam.Nutr.Res. DeFelice SL and Gilgore SG. Wadman, R. I., Bosboom, W. M., van den Berg, L. H., Wokke, J. H., Iannaccone, S. T., and Vrancken, A. F. Drug treatment for spinal muscular atrophy types II and III. Eur J Clin Pharmacol 1998;54:503-8. J Formos.Med.Assoc. Koeth RA, Wang Z, Levison BS, Buffa JA, Org E, Sheehy BT, Britt EB, Fu X, Wu Y, Li L, Smith JD, DiDonato JA, Chen J, Li H, Wu GD, Lewis JD, Warrier M, Brown JM, Krauss RM, Tang WH, Bushman FD, Lusis AJ, Hazen SL. Pola, P., Tondi, P., Flore, R., Serricchio, M., Dal Lago, A., Amanti, C., Consorti, F., Benedetti, M., and Midiri, H. Effect of l-carnitine on lipid pattern in debilitated patients treated with Intralipid. B., Gokcay, G., Grunewald, S., Guffon, N., Maier, E. M., Morava, E., Geb, S., Schwahn, B., Walter, J. H., Wendel, U., Wijburg, F. A., Muller, E., Kolker, S., and Horster, F. Diagnostic work-up and management of patients with isolated methylmalonic acidurias in European metabolic centres. Pediatr Hematol Oncol. Pande, S., Brion, L. P., Campbell, D. E., Gayle, Y., and Esteban-Cruciani, N. V. Lack of effect of L-carnitine supplementation on weight gain in very preterm infants. Zhao, J. L., Gao, D. Z., Liu, D., He, H. H., She, Q., and Yin, Y. H. Improvement of exercise tolerance by L-carnitine in patients with cardiac syndrome X. Chin.Hosp.Pharm.J. Muscle carnitine deficiency in patients using valproic acid. Is Acetyl-L-Carnitine Good for Your Mental Health? Sports Med 1996;22:109-32. Int J Clin Pharmacol Ther Toxicol 1988;26:217-20. Drugs R D 2002;3:223-31. Insomnia; Diarrhea; Some . Does L-carnitine reduce belly fat? [The impact of L-carnitine administration on the serum level of myocardium injury markers in patients with acute carbon monoxide poisoning]. Can carnitine cause insomnia? Increased urinary excretion of carnitine in patients treated with cisplatin. View abstract. Physiologie. Loffredo, L., Marcoccia, A., Pignatelli, P., Andreozzi, P., Borgia, M. C., Cangemi, R., Chiarotti, F., and Violi, F. Oxidative-stress-mediated arterial dysfunction in patients with peripheral arterial disease. BJU Int 2001;88:63-7.. View abstract. Int J Clin Pharmacol Res 1983;3(3):179-184. Effects of Citric Acid and l-Carnitine on Physical Fatigue. View abstract. View abstract. L-Carnitine Benefits, Side Effects & Dosage - SelfHacked View abstract. Novak M. Carnitine supplementation in soy-based formula-fed infants. Schlenzig JS, Charpentier C, Rabier D, et al. Calo, L. A., Pagnin, E., Davis, P. A., Semplicini, A., Nicolai, R., Calvani, M., and Pessina, A. C. Antioxidant effect of L-carnitine and its short chain esters: relevance for the protection from oxidative stress related cardiovascular damage. Iyer, R. N., Khan, A. J NeuroAIDS. Hatamkhani S, Khalili H, Karimzadeh I, Dashti-Khavidaki S, Abdollahi A, Jafari S. Carnitine for prevention of antituberculosis drug-induced hepatotoxicity: a randomized, clinical trial. Zhonghua Nan.Ke.Xue. Zhang, W., Miao, J., Zhang, G., Liu, R., Zhang, D., Wan, Q., Yu, Y., Zhao, G., and Li, Z. Med.Sci Monit. Onofrj M, Fulgente T, Melchionda D, et al. Clin Hemorheol.Microcirc. Control of valproate-induced hepatotoxicity with carnitine. 2007;44(2):83-90. Kidney Int 1990;38(5):904-911. The effect of L-carnitine supplement on dialysis patients [abstract]. [A systematic review of the effectiveness of alternative weight-loss products' ingredients]. View abstract. Brevetti G, Perna S, Sabba C, et al. Nephron 38 (1984): 120-4, 6. Turpeinen AK, Kuikka JT, Vanninen E, and et al. Metabolism 2007;56(8):1118-1123. View abstract. View abstract. Some dosage forms listed on this page may not apply to the brand name L-Carnitine. BMC Public Health. Cardiovasc.Drugs Ther 1999;13:537-46. Pharmacokinetic comparisons of two acetyl-L-carnitine formulations in healthy Korean volunteers. Wang DD, Wang TY, Yang Y, He SM, Wang YM. View abstract. Safety, tolerability and symptom outcomes associated with L-carnitine supplementation in patients with cancer, fatigue, and carnitine deficiency: a phase I/II study. View abstract. J Nutr 2007;137(3 Suppl 2):847S-849S. View abstract.